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While early safety data appear favorable, the potential for proangiogenic activity to influence oncogenic processes underscores the importance of comprehensive cancer pre-screening prior to therapeutic use

3.3 Dysregulation of host haem-iron homeostasis High iron availability has been shown to increase the pathogenic potential of many bacteria in tissue and animal infection models by enhancing growth, cellular adhesion, invasion and epithelial damage (Reid et al., 2009

Remember consistency is important

In this context, we recognize the evolving landscape of in vitro liver models and intend to explore PHH spheroid models and co-culture spheroid models, which incorporate non-parenchymal cells, in future studies to further assess their functionality and to provide a comprehensive comparison with our iHLO model, thereby continuously advancing the field

Habtu, Y.G